Several mechanisms have been reported to contribute to the development of docetaxel-resistance, including mutations in microtubule, evolution of cancer stem cells, elevation of Multi-Drug Resistance (MDR) family of efflux transporters, re-activation of androgen receptor (AR) signaling, upregulation of PI3K-AKT signaling [8], as well as dysregulation of PPARα (peroxisome proliferator-activated receptor α) signaling and CDH1 gene [10]. This evidence concerns the gene AR and cancer.