Given that FcεRIα was upregulated in CGRP+ nociceptors and MrgprA3+ pruriceptors in ACJ, and IgE-IC could evoke acute ocular itch through neuronal FcεRIα, we next asked whether neuronal FcεRIα was involved in ocular itch under allergic conjunctivitis condition. This evidence concerns the gene IGHE and atopic conjunctivitis.