Given that FcεRIα was upregulated in CGRP+ nociceptors and MrgprA3+ pruriceptors in ACJ, and IgE-IC could evoke acute ocular itch through neuronal FcεRIα, we next asked whether neuronal FcεRIα was involved in ocular itch under allergic conjunctivitis condition. The gene discussed is FCER1A; the disease is atopic conjunctivitis.