CD274 and breast carcinoma: To investigate the role of IGF2BPs in the modulation of PD-L1 mRNA, IGF2BP1–3 was knocked down in breast cancer cells, and our results showed that PD-L1 expression was significantly inhibited by IGF2BP3 knockdown (Fig. 3a, Additional file 3: Fig. S3b) instead of IGF2BP1/2 disruption (Additional file 3: Fig. S3a).