Following the treatment as described above (Additional file 4: Fig. S4a), indeed the silencing of METTL3 or IGF2BP3 could suppress tumor growth (Fig. 4g), tumor weight, and volume, similar to effects observed upon PD-L1 blockade treatment; PD-L1 overexpression was able to partially rescue tumor growth (Fig. 4g, h, Additional file 4: Fig. S4b, c). Here, METTL3 is linked to neoplasm.