CHEK1 and hepatocellular carcinoma: In the network, hsa-miR-15a-5p potentially target and silence RACGAP1, SPC24, KIF18B, CDCA7L, and ANLN; hsa-miR-30a-5p potentially target and silence CENPM; hsa-miR-148a-3p potentially target and silence VIPR1, PRR11, ANLN, and PRC1; hsa-miR-199a-5p potentially target and silence CDCA7L, CENPM, E2F2, RNF152, KIF2C, CHEK1, CDC6 and MCM10. Silencing these genes could repress HCC progression through multiple mechanisms.