PROS1 and Hyperglycemia: According to the results of the present study, we hypothesize that prolonged hyperglycemia may result in retinal inflammation in patients with DR, which is responsible for the deregulation of the endothelial cells of retinal vessels (inner BRB) as well as the retinal pigment epithelium (RPE) cell junction proteins (outer BRB) and impacts the blood supply of choroid.