Similarly, the levels of IFN-γ released from CD84− PBMCs from pulmonary TB patients after anti-CD3 or ESAT-6 stimulation were also significantly higher than the levels released from CD84+ PBMCs (Fig. 3f), indicating that CD84 can suppress the IFN-γ release in TB patients that is associated with a Th1 immune response against M. tuberculosis infection (39). This evidence concerns the gene IFNG and tuberculosis.