We interpreted the action of the TH-GPT2 axis as part of the pro-hypertrophic programs triggered by THs, which indeed, together with accelerated catabolism, are involved in the promotion of futile cycles (Vaitkus et al., 2015), which is also underlined by the fact that muscle weakness and fatigue are common to both hypo- and hyperthyroidism in humans (Argov et al., 1988). This evidence concerns the gene GPT2 and hyperthyroidism.