Finally, beside the skeletal muscle, the TH-GPT2-anaplerosis axis could be part of the pro-glycolitic and pro-Warburg effects exerted by TH and GPT2 in cancer, in which anaplerosis is a keystone of the metabolic reprogramming of cancer cells (Miro et al., 2021; Smith et al., 2016). This evidence concerns the gene GPT2 and cancer.