They showed that SSc myofibroblasts arise from a SFRP2hi DPP4+ progenitor fibroblast population in two steps: an initial global shift of SFRP2hi WIF1+ to SFRP2hi PRSS23+ WIF1− fibroblasts, only a subset of which subsequently differentiate into myofibroblasts also expressing SFRP4 and FNDC1.55 The gene discussed is WIF1; the disease is systemic sclerosis.