TNF and atherosclerosis: In addition, the top 15 KEGG pathways related to hub targets were AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, drug metabolism-cytochrome P450, TNF signaling pathway, insulin resistance, etc. According to previous statistic, the pathways of AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, and insulin resistance were also enriched in non-alcoholic fatty liver and involved in the regulation of liver function [53].