A previous study of GTE treatment (302 mg EGCG and ~9 mg caffeine) or placebo for 12 weeks in obese women (16–60, average age 43 years) showed those receiving GTE exhibiting reduction in waist circumference and LDL cholesterol and increased in HDL cholesterol, adiponectin, and ghrelin when compared to baseline levels, but no significant differences in weight, BMI, and waist circumference and no significant changes in obesity-related hormone levels when compared with a control group [68]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.