LCAT and breast carcinoma: For the other hub genes related to the prognosis of HCC, LCAT (Lecithin-cholesterol acyltransferase) is a plasma enzyme involved in reverse cholesterol transport (RCT) and high-density lipoprotein (HDL) metabolism and has been reported to play an important role in many other cancers, such as breast cancer [15], Hodgkin lymphoma [16], and ovarian cancer [17].