In addition, a previous study confirmed that SORBS1 forms a complex with AHNAK nucleoprotein (AHNAK), which functions as a tumor suppressor by inhibiting phosphorylated extracellular regulated kinase (ERK) and Rho-associated coiled-coil containing protein kinase 1 [38]; therefore, we speculate that SORBS1 may regulate the development of LUAD by affecting the activities of ERK and Rho. This evidence concerns the gene RHO and neoplasm.