A more detailed assessment of Fc-mediated effector functions of Env-specific plasma IgG revealed that vaccine virus-specific ADCC activity was associated with fewer challenges required for infection (r = −0.761 and unadjusted P = 0.0054), but this inverse correlation did not reach statistical significance after adjustment for multiple-parameter analysis (adjusted P = 0.0984) (Table 2). The gene discussed is ERVW-1; the disease is infection.