MAPT and Mental deterioration: When we modeled the relationship between DRS score decline and baseline plasma P-tau or NfL biomarkers in all subjects with AD pathology (Fig. 6b–d), we found that cognitive decline was steeper in patients with high (i.e., above our ROC-defined cutoffs) baseline plasma P-tau181 (> 3.64 pg/mL) or P-tau231 (> 10.5 pg/mL) levels than in those with low (below cutoff) levels of these plasma biomarkers.