We examined plasma biomarkers in other common age-related pathologies that can cause dementia, including two key pathologic features of LATE: HS which has been assessed on all cases) and abnormal hippocampal TDP-43 accumulation of LATE (which was assessed in a subset—see below), and LBD (defined as limbic or neocortical stages of α-synuclein pathology). This evidence concerns the gene TARDBP and dementia.