PRKAA2 and cancer: Moreover, AMPK is activated under diverse micro-environmental stress conditions encountered by cancer cells, such as glucose deprivation, hypoxia and matrix-deprivation, and brings about cancer cell survival, thus aiding tumour progression (Hindupur et al., 2014; Jeon et al., 2012; Kumar and Rangarajan, 2009; Saha et al., 2018).