LDHA and neoplasm: In vitro serial sphere-forming potential serves as a surrogate for self-renewal and in vivo tumour initiation potential (Rajasekhar et al., 2011), and tumour-initiating cells can also be enumerated using CD44high/CD24low marker profile (Al-Hajj et al., 2003) and high ALDH activity (Clark and Palle, 2016).