PRKAA2 and cancer: Anoikis resistance of cancer cells is achieved by AMPK activation-mediated PEA15 phosphorylation (Hindupur et al., 2014) and NADPH homeostasis by inhibition of acetyl-CoA carboxylase (ACC) (Jeon et al., 2012), as well as the direct inhibition of mammalian target of rapamycin complex 1 (mTORC1) (Ng et al., 2012).