Sepsis, liver diseases, ischemia-reperfusion (I/R) injury (myocardial and cerebral I/R injury), cardiovascular diseases such as chronic heart failure, coronary artery diseases, aortic dissection and atrial fibrillation, chronic obstructive pulmonary disease, metabolism-related diseases including diabetes mellitus, obesity, cancer and aging are among the disorders influenced by SESN2.11 The gene discussed is SESN2; the disease is atrial fibrillation.