In ROC analysis of irisin (Figure 2) and nesfatin-1 (Figure 3), cut-off levels for MS were 10.390 (ng/mL) (sensitivity: 84.1%, specificity: 71.4%, PPV: 81.08%, NPV: 75.51% AUC: 0.800 (0.704-0.896), and 7.155 (ng/mL) (sensitivity: 68.2%, specificity: 64.3%, PPV: 65.85%, NPV 66.67%: AUC: 0.739 (0.636-0.842) respectively. The gene discussed is NUCB2; the disease is myeloid sarcoma.