21 Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, et al. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. The gene discussed is C1QTNF3; the disease is obesity due to melanocortin 4 receptor deficiency.