INS and Large for gestational age: The studies showed the use of metformin caused lower neonatal weights, due to its ability to decrease insulin concentration by crossing the placental barrier.(13-16) Glyburide, on the other hand, caused increased birth weight, although it did not show higher numbers of newborns with macrosomia.(12,14-16) Furthermore, weight gain during pregnancy was lower in the groups that used metformin when compared to the Glyburide Group, due to the drug action.(12,14)