INS and gestational diabetes: These findings lead to the assumption that glyburide should be avoided in the treatment of GDM when metformin and insulin are available.(2,17,18) Among the possible outcomes of using both oral drugs are treatment failure, in which it is necessary to switch to insulin therapy, a change in the pharmacokinetics of the drug, the occurrence of general diseases in neonates, and maternal morbidity.(12,16)