It was also noted other studies compared several outcomes, such as pregnancy-induced hypertension, hypertensive disorders, and preeclampsia; but compared only metformin and insulin, or glyburide and insulin, whereas this study compared metformin and glyburide.(2,17,18) This study assessed outcomes different from those of other reviews, such as the need for neonatal intensive care, and was based on more current RCTs. This evidence concerns the gene INS and preeclampsia.