CASP1 and primary biliary cholangitis: Injection of polyI: C results in increased MDA content and decreased GSH-px/SOD activity in the liver tissues of mice, then oxidative stress is generated in the body and NLRP3 was activated, posing up-regulated L-1β, IL-18 and caspase-1, as well as the occurrence of inflammation response, thereby causing liver damage and fibrosis and finally the preparation of PBC mouse model.