A screening approach was used in a genome-wideapproach to identify patient tumor-expressed mutated proteins, followedby synthesis and evaluation of mutated T cell epitopes as candidatesbased on modeled MHC binding ability for recognition by TILs.355 This led to the identification of mutated antigensexpressed on autologous tumor cells recognized by TILs from threeindividuals with melanoma where tumor regression was observed followingadoptive transfer of TILs. The gene discussed is HLA-C; the disease is neoplasm.