Tumor-reactive CTLs associated with melanocytesand melanoma bindto peptide antigens from the Melan-A/MART-1 gene.138 Melan-A-specific CTLs (HLA-A*02:01-restricted) recognizemainly the Melan-A27–35 (AAGIGILTV) and theMelan-A26–35 (EAAGIGILTV) peptides. This evidence concerns the gene MLANA and melanoma.