In addition, we found that three (CDX1, CDX2, and KLF4) of the four transcription genes (CDX2, KLF4, CDX1, and ELF3) with low expression in CSCC also showed low expression in colorectal adenocarcinoma,20, 21, 22, 23 while ELF3 achieved the opposite result in colorectal adenocarcinoma.24 Here, CDX1 is linked to colorectal adenocarcinoma.