In addition, we found that three (CDX1, CDX2, and KLF4) of the four transcription genes (CDX2, KLF4, CDX1, and ELF3) with low expression in CSCC also showed low expression in colorectal adenocarcinoma,20, 21, 22, 23 while ELF3 achieved the opposite result in colorectal adenocarcinoma.24 The gene discussed is KLF4; the disease is colorectal adenocarcinoma.