Knockdown of hsa‐miR‐424 or overexpression of AC020907.1, Y_RNA, TMEM72‐AS1, KRT16P2, DLX6‐AS1, AP002414.1, and TBPL1 could regulate these three pathways to suppress malignant glioma tumorigenesis and progression. The gene discussed is TMEM72; the disease is malignant glioma.