Fourteen genes within the cellular senescence pathway (AC020907.1, Y_RNA, TMEM72‐AS1, KRT16P2, DLX6‐AS1, AP002414.1, hsa‐miR‐424, TBPL1, NPAS2, CRY2, C9ORF40, AL136115.1, AC102941.1, and AC008738.2) were used to construct a model to evaluate the importance of these genes in malignant glioma. The gene discussed is DLX6; the disease is malignant glioma.