ABCA4 and Stargardt disease: The consensus appears to be that p.Gly1961Glu is a moderate mutation.[5,24] In the homozygous state, it presents a mild form of STGD1; in the compound heterozygous state with a more deleterious mutation, it can contribute to a severe form of Stargardt disease.[5] As in other populations, p.Gly1961Glu may be relatively common among Iranian STGD1 patients, as it was observed in two patients of the relatively small cohort studied here.