Due to the importance of tankyrase in Wnt/β-catenin signaling, using TNKS inhibitor in several diseases including cancer (colon, lung, and prostate), cherubism, and systemic sclerosis, Epstein Barr and Herpes simplex viral infections, fibrotic diseases, and others have been investigated before (17-20). Here, TNKS is linked to systemic sclerosis.