To investigate whether miR-142 overexpression influences the expression of EGFR signaling pathway oncogenes in U-87 glioblastoma cells, real-time PCR and western blotting were performed on 5 of its predicted target genes, KRAS, AKT1, PIK3CA, MAPK8, and SHC4 at 72 h after transduction. The gene discussed is SHC4; the disease is glioblastoma.