RAC1 and glioblastoma: Qin et al., showed that miR-142 is downregulated in tissues of patients with GBM and its ectopic overexpression in glioblastoma cell lines suppressed cell migration and invasion by targeting Ras-related C3 botulinum toxin substrate 1 (RAC1), leading to suppression of matrix metalloproteinases (MMPs) (24).