BDNF and ischemia: The latest study conducted on BDNF application used polymer-based polyethylene glycol-polyaspartic acid (DET) nano micelles and its derivatives to administer BDNF-encoded mRNA into the brain, which significantly increased transient whole brain expression of BDNF. The results showed an increase in the survival rate of hippocampal neurons after ischemia (TGI) and a rapid increase in BDNF content in the hippocampus after administration.