BDNF and experimental autoimmune encephalomyelitis: To overcome the challenge of the inability of BDNF to pass through the blood-brain barrier, researchers have begun to identify ways to improve the permeability of BDNF. At present, studies have used BDNF and the BBB modulator (BBBM) peptide, ADTC5, to deliver recombinant brain-derived neurotrophic factors to the brains of healthy mice and experimental autoimmune encephalomyelitis (EAE) mice through intravenous injection.