IGHE and chronic rhinosinusitis with nasal polyps: In a Japanese study, the researchers classified patients with CRSwNP into eosinophilic (N = 42), neutrophilic (N = 27), and non–eosinophilic non–neutrophilic (N = 61) types and reported higher IgE values and expressions of Eotaxin, IL–17A, and CD68 in eosinophilic type, which suggest different pathophysiology between these groups (21).