SPOP and posterior cortical atrophy: In PCa, oncoproteins including AR [11], BRD4 [12, 13], SRC-3 [14], DEK [15], TRIM24 [16], PD-L1 [17, 18], 17βHSD4 [19], HIPK2 [20], ZMYND11 [21] and ERG [22] are well-known substrates of SPOP.