We further demonstrated that ASXL3 is highly expressed and also essential for cell viability in SCLC cells by controlling the transcription of a number of SCLC essential genes such as PAX9, WDR72, CDH7, BCL2, etc., which are also direct transcriptional target of BAP1 [11, 41]. The gene discussed is BCL2; the disease is small cell lung carcinoma.