ASXL3 and small cell lung carcinoma: Therefore, to determine how iBAP-II regulates transcription in SCLC cells via ASXL3 protein, we conducted RNA-seq in NCI-H1963 cells treated with different concentrations of either iBAP or iBAP-II (Supplementary Fig. 2D) and further compared the gene expression profile between iBAP/iBAP-II treated cells and ASXL3-depleted cells.