Besides targeting just histone substrates, BAP1 can also function as a deubiquitinase of non-histone proteins, such as HCFC1 [14], KLF5 [21], INO80 [22], DNMT1 [23], IP3R3 [24], and PGC1-α [25], most of which have been reported as key regulators in human cancers. The gene discussed is BAP1; the disease is cancer.