FH and paroxysmal nocturnal hemoglobinuria: Mutations in FH, FHRs, or other complement-related genes are associated with diseases such as age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathies (C3G), and paroxysmal nocturnal hemoglobinuria (PNH)8,16.