Mutations in FH, FHRs, or other complement-related genes are associated with diseases such as age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathies (C3G), and paroxysmal nocturnal hemoglobinuria (PNH)8,16. The gene discussed is FH; the disease is complement 3 glomerulopathy.