Given this limitation of our experimental approach and to account for possible confounding genomic and non-genomic effects of other TRPC channels caused by global loss of TRPC631, we performed also studies using two different TRPC6 blockers SH045 and BI-749327 in C57BL/6 J WT mice to evaluate the role of TRPC6 in short-term AKI outcomes. The gene discussed is TRPC6; the disease is acute kidney injury.