Consistent with AKI data from Trpc6−/− and WT mice, pharmacological blockade of TRPC6 had no effects on serum creatinine levels after 17.5 min or 20 min IRI-induced AKI in comparison to vehicle injected WT IRI mice (P = 0.23 and P = 0.76, respectively, Fig. 5C). Here, TRPC6 is linked to acute kidney injury.