Previously, it was reported that the DRAK1 transcript level was directly upregulated by p53 bound to an upstream element of the DRAK1 gene and that DRAK1 knockdown resulted in cisplatin resistance in human embryonal carcinoma cells [29]; however, it had not been determined whether the DRAK1 protein levels were regulated through posttranslational modifications. This evidence concerns the gene TP53 and embryonal carcinoma.