Also, through immunohistochemistry (IHC) staining of xenograft tissues, we observed that the expression level of DRAK1 was downregulated, whereas those of TRAF6 and Ki67, a marker of cell proliferation, were upregulated in paclitaxel-resistant tissues (Fig. 1I), suggesting that the suppression of DRAK1 protein level and induction of TRAF6 expression were related to the tumor progression of HeLa/PTX cells. The gene discussed is MKI67; the disease is neoplasm.