Therefore, our work was designed to probe whether lncRNA SNHG1 influenced cirrhosis and the potential mechanism, and thus illustrated that silencing of lncRNA SNHG1 might promote HLC differentiation of BMSCs to protect against cirrhosis by activating UVRAG/ATG5/Wnt5a axis via downregulation of miR-15a-targeted SMURF1. Here, WNT5A is linked to Cirrhosis.