SMURF1 and Hepatic fibrosis: Briefly, lncRNA SNHG1 silencing was observed to downregulate SMURF1 by upregulating miR-15a, diminishing ubiquitination of UVRAG to activate ATG5/Wnt5a axis, which accelerated HLC differentiation from BMSCs and repressed liver fibrosis to inhibit cirrhosis (Fig. 10).