Further, we testified the findings in the cirrhosis mouse model and obtained similar results as in vitro experiments: injection of SMURF1 overexpression HGF-induced BMSCs aggravated the degree of cirrhosis in mice, which was abolished by oe-UVRAG, rapamycin, or recombinant Wnt5a (Supplementary Table 4). The gene discussed is SMURF1; the disease is Cirrhosis.