Of note, overrepresented pathway analysis revealed that the GPx2 KD tumor was enriched in key signaling pathways including EIF2 signaling, OXPHOS, mitochondrial dysfunction, Sirtuin signaling, glycolysis, and mammalian target of rapamycin (mTOR) signaling, among others (Fig. 5B), which likely form a coordinated adaptive response to oxidative stress and hypoxia elicited by GPx2 loss. Here, GPX2 is linked to neoplasm.