HIF1A and neoplasm: Our scRNA-seq data confirmed a fivefold reduction in GPx2 mRNA in the GPx2 KD tumor (SI Appendix, Fig. S7 A and B) and violin plots confirmed a dramatic increase in HIF1α and VEGFA mRNAs in most of the clusters that make up the GPx2 KD tumor (SI Appendix, Fig. S7 C and D).