CTLA4 and Miyoshi myopathy: As for the dual blockade of CTLA-4 and PD-1 pathways, a pooled analysis showed that among patients with MM who received the combination of nivolumab plus ipilimumab, the ORR (37.1%) and the median PFS (5.9 months) were only slightly improved than CTLA-4 or PD-1 blockade alone,16 while the median OS was not mature.