Previous studies showed that IFNγ receptor deficient (IFNGR1-/-) mice develop more tumors than wild-type mice and that the IFNγ- responsiveness of the tumor cell is essential for effective immune recognition.32 33 Hence, upregulated IFNGR1 in tumor cells can potentially collaborate with lymphocytes to shape the immunogenic phenotype of tumors and facilitate the effective immune recognition.24 32 33. This evidence concerns the gene IFNG and neoplasm.