To mount an adaptive immune response, DCs must incorporate antigens from tumor cells, acquire the competence of antigen processing in a maturation step and present antigenic peptides bind to major histocompatibility complex (MHC) molecules to recognition by specific T cells.27 Loss of YTHDF1 in GC tumor cells increased tumor infiltrating mature DCs and boosted the expression of surface MHCII molecules in intratumoral DCs, thereby promoting an effective adaptive immune response. The gene discussed is HLA-C; the disease is neoplasm.