Microarray analysis of pretreatment and post-treatment pairs of tumor biopsy (or liquid biopsy of tumor-associated ascites/pleural effusion), obtained the day before and average of 8 weeks after oncolytic immunotherapy, revealed decrease of TIM-3 expression in nine patients, whereas six patients displayed increase of TIM-3 (online supplemental table S1). Here, HAVCR2 is linked to neoplasm.