Other TIM-3 ligands, carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1) and phosphatidylserine synthase (PTDSS1, not shown), which are ubiquitously expressed by tumor cells,10 showed overall reduction likely due to oncolysis and remodeling of the tumor microenvironment (online supplemental table S2). The gene discussed is HAVCR2; the disease is neoplasm.