CEACAM1 and neoplasm: Other TIM-3 ligands, carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1) and phosphatidylserine synthase (PTDSS1, not shown), which are ubiquitously expressed by tumor cells,10 showed overall reduction likely due to oncolysis and remodeling of the tumor microenvironment (online supplemental table S2).