The COVID-19 disease might be influenced by angiotensin-converting enzyme (ACE), ACE2, and Type 2 transmembrane serine proteases (TMPRSS2) genotypes, with previous studies reporting that allele frequencies and single nucleotide polymorphisms (SNPs) are correlated with individual variations in prevalence of COVID-19 among ethnic groups [12]. This evidence concerns the gene TMPRSS2 and COVID-19.