With regard to CRMO, Aggregatibacter is known to disrupt neutrophil membrane integrity via Leukotoxin A (LtxA) and thereby reduces and dysregulates neutrophils, a cell population under strong suspicion to be a causative agent for autoinflammation in CRMO animal models via (pro-)IL-1β [20, 88]. This evidence concerns the gene IL1B and chronic recurrent multifocal osteomyelitis.