TNF and Sepsis: Some other anti-inflammatory agents that may also be used in sepsis include ulinastatin, which is a serine protease inhibitor that can reduce IL-6, IL-8, TNF-α, and CRP and can alleviate injury of mitochondria and has anti-oxidant effects; thymosin α-1 (Tα1), which is a thymic peptide regulates immune system and so can decrease mortality rate in septic patients [14]; and anisodamine, another medicinal treatment choice for septic shock.