According to Lu et al., HSP700 plays cytoprotective roles in AD, blocks Aβ self-assembly, moderates caspase-dependent and caspase-independent apoptotic pathways and reduces it in neuron cells, it also directly prevents tau aggregation and enhance Aβ clearance by upregulates the expression of insulin degrading enzyme and transforming growth factor beta [57]. This evidence concerns the gene INS and Alzheimer disease.