A haptoglobin concentration greater than 2.7 g/l in the moderate CFH group and greater than 2.4 g/l in the high CFH group was identified as a clinical cutoff value to protect from CFH-associated AKI with near certainty (sensitivity 89.5% [95% CI, 83–96] and 90.2% [95% CI, 80–97], respectively). The gene discussed is HP; the disease is acute kidney injury.