However, in comparing CSF neuroinflammatory proteins before and after the induction of hydrocephalus, the levels of the interleukins IL6 and IL8 were found to significantly increase (p = 0.0002, t = − 4.7, F = 9.818 Student’s t-test for IL6; p = 0.0032, t = − 3.405, F = 1.397 Student’s t-test for IL8) (Fig. 7F, G). This evidence concerns the gene CXCL8 and Hydrocephalus.