IL-6 is a key cytokine involved in B cell activation [20] and the results from the cytokine assay indicated that patients with IC/BPS-HL, when compared to their age and sex matched IC/BPS-NHL counterparts, displayed significantly higher average urinary concentrations of IL-6 (Fig. 3A; HL: 3.23 pg/mL; NHL: 1.61 pg/mL; p = 0.0054). The gene discussed is IL6; the disease is non-Hodgkin lymphoma.