In addition, LRRK2 and p-Rab10 expression were significantly increased in THP-1 cells cultured with PD RBC-EVs, while LRRK2 and p-Rab10 were only slightly increased in THP-1 cells treated with HC RBC-EVs (Fig. 7I–K). The gene discussed is LRRK2; the disease is Parkinson disease.