POLE and cancer: In addition, we collected some cancer drive genes and immunotherapy-related genes (including EGFR, ALK, KRAS, TP53, MUC16, MET, BRCA1, BRCA2, POLE, POLD1, MSH2, STK11, BRAF, PIK3CA, HER2, FGFR1, ROS1) [51].