Overexpression of PEDF in mice by intravitreous injection of an adenoviral vector encoding PEDF (AdPEDF) and PEDF transgenic mice have been reported to block laser-induced choroidal neovascularization (CNV) and VEGF-induced retinal neovascularization [21, 22]. Here, SERPINF1 is linked to choroidal neovascularization.