In GSE14520 cohort (Table 4), tumor size, cirrhosis, and BCLC stage were considered as adjusted factors in the multivariate Cox regression model, which suggested that high expression of CDK1 (adjusted HR = 2.237; adjusted P < 0.001) and CDK4 (adjusted HR = 1.579; adjusted P = 0.044) were statistically related to OS in HBV-infected HCC patients. This evidence concerns the gene CDK4 and hepatocellular carcinoma.