Overexpression of CDK1 and CCNB1 can promote HCC cell proliferation and migration through the mitogen-activated protein/extracellular signal-regulated kinase (MEK/ERK) signaling pathway, and trials of MEK1/2 inhibitors for the treatment of HCC are currently underway [51, 52]. The gene discussed is MAP2K1; the disease is hepatocellular carcinoma.