Data showing that FGFR4 is overexpressed in invasive ductal carcinomas and that FGF15/19 signalling mediates the survival of a subset of basal-like breast cancer through FGFR4 and PI3K–AKT signalling confirm the link between metabolism alterations due to FGFR4 levels, survival and an aggressive breast cancer phenotype [227,229]. Here, AKT1 is linked to breast carcinoma.