In addition to AKT and ERK1/2 activation, FGFR1 induces the activation of the IGF1R pathway through the recruitment of IRS1 in breast cancer cells resistant to the inhibitor metformin, thus suggesting a connection between growth factor mitogenic signalling and glucose metabolism in breast cancer cells [190] (figures 1 and 4). This evidence concerns the gene IRS1 and breast carcinoma.